5-HT2A/2B/2C receptors, memory and therapeutic targets (CAPÍTULO)

Abstract
The 5-HT2 receptors subdivision into the 5-HT2A/2B/2C subtypes along with the advent of the selective antagonists has allowed a more detailed investigation on the role and therapeutic significance of these subtypes in cognitive functions. It is suggested that, 5-HT2B/2C receptors might be involved on memory formation probably mediating a suppressive or constraining action. Whether the drug-induced learning impairments in this study are explained by simple agonism, antagonism or inverse agonism at 5-HT2 receptors remains unclear at this time. Notably, the 5-HT2 receptor subtypes blockade may provide some benefit to reverse poor memory consolidation conditions associated with decreased cholinergic, glutamatergic, and/or serotonergic neurotransmission.