Abstract
This study explores the potential link between COVID-19 vaccination and the onset of multiple sclerosis (MS) in children aged 9 to 12 years in Puebla, Mexico. Among 40 children observed—23 girls and 17 boys—MS symptoms emerged predominantly within 3 to 6 months post-vaccination. The findings reveal a temporal association between vaccination and MS onset, with girls showing a higher prevalence and more severe progression. The study underscores the need for further research into the immunological mechanisms that may connect vaccination with autoimmune responses, particularly in pediatric populations predisposed to such conditions. These results highlight the importance of careful monitoring and tailored vaccination strategies to mitigate risks in vulnerable groups.