Abstract

Background: Early identification of different COVID-19 clinical presentations may depict distinct pathophysiological mechanisms and guide management strategies.

Objective: To determine the aggressiveness of SARS-CoV-2 using symptom progression in COVID-19 patients.

Design: Historic cohort study of Mexican patients. Data from January-April 2020 were provided by the Health Ministry.

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Obesity remains as a global epidemic characterized by progressive metabolic dysregulation in glucose homeostasis. Along with a genetic association in the development of T2D, epigenetic regulation has been suggested as a significant contributor in altered gene expression. Recent studies have described DNA methylation changes in insulin-sensitive tissues involved in T2D pathogenesis, however epigenetic dynamics on early stages to metabolic alterations is still unclear.

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Background: Most patients with cerebral palsy (CP) do not respond to physical therapy due to deterioration in their nutritional status, secondary to gastrointestinal disorders and the catabolic state of the disease itself. However, basic treatments only contemplate the energy requirements and do not consider supplementation with glutamine, zinc, selenium, colecalciferol, spirulina, omega 3 or even vegetal proteins.

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